Inhibition of therapeutic protein aggregation by cyclodextrins
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Inhibitory effect of corcin on aggregation of 1N/4R human tau protein in vitro
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A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFN2b) has poor stability and undergoes physical degradation. The aim of this study was to investigate the effect of solution conditions on the heat-induced aggregation of rhIFNα2b. The protein was incubated for 1 h at 40°C–70°C and for up to 240 h at 50C...
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تاریخ انتشار 2010